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KMID : 0606320040210010114
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Journal of Phamacetical Sciences Sookmyung Women s University
2004 Volume.21 No. 1 p.114 ~ p.120
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Genetic diversity of DPD,TS, and MTHFR in a Korea Population
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Yang Mi-Hi
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Abstract
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In order to do effcient treatment of 5-Fluorouracil (5-FU) in Koreans, we investigated genetic polymorphisms of dehydropyrimidine dehydrogenase DPD; gene,DPYD), thymidylate synthase (TS), and methyltetrahydrofolate reductase, (MTHFR), which are involved in 5- FU metabolism or efficacy in a korean population. As results, we found genetic polymorphisms inDPYD-85,-1627, and -1896 site, T5-5’ER, and -3’UTR and MTHFR-222,429 site among the Koreans (normal, N=105; head and neck cancer patients, N=28).5-FU efficacy was determined into PR(partial response, decrease of cancer size over 50%) and SD (stab1e disease). Each or combination of the above 7 genetic polymorphisms were not associated with 5-FU efficacy. Therefore, the studied 7 genotypes can not be considered to result in Individual variation in 5-FU efficacy.
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